The Law of Laplace (Press) calculator computes the pressure (P) on the membrane wall of based on the wall stress (H), radius of the chamber (r) and the vascular wall thickness (T).
INSTRUCTIONS: Choose your preferred units and enter the following:
Pressure: The pressure (P) is computed in Milli-pascals (mPa). However this can be automatically converted to other pressure units via the pull-down menu.
Heart / Blood Calculators:
The Pressure Law of Laplace formula, P= (2⋅H⋅T)/r is based on Laplace's Law (physics) and is applied in the physiology of blood flow. Under equilibrium conditions the wall stress on a heart chamber containing a fluid is proportional to the pressure in the chamber and the radius of the chamber for a spherical approximation. This law is called either Laplace's Law or the Law of Laplace.
Laplace's Law is a law of physics that is applied in the physiology of blood flow. Under equilibrium conditions the pressure on a vessel containing a fluid is proportional to the wall stress and inversely proportional to the radius of the vessel for a sphere and the pressure is half of this for a tube. This law is called either Laplace's Law or the Law of Laplace.
For a given pressure, increased radius requires increased wall thickness to accommodate a stable wall stress; also, increased pressure requires increased thickness to maintain a stable wall stress. The latter is used to explain thickening of arteries and thickening of the left ventricle to accommodate high blood pressure. However, the thickened left ventricle is stiffer when the thickness is normal, so it requires elevated pressures to fill, a condition known as diastolic heart failure.
Using the physiological application of the Law of LaPlace we can examine the course of systolic heart failure. As the systolic heart failure continues, the end-diastolic volume of the heart might increase. With volume increase the radius increases and the Law of Laplace equation then tells us the pressure generated decreases. This makes the heart problem worse, as the failing ventricle has to work harder to keep up the blood pressure. The dilated ventricle requires more wall stress in the wall to generate the same pressure.
The wall stress, here the left ventricle's wall stress, is produced by the force acting against the myocardial cells.
This wall stress is directly proportional to left ventricle's pressure and radius. This simple relationship helps us understand what conditions can affect oxygen flow and which therapies can relieve angina. The following are some of the ways the pressure/radius/wall thickness/wall stress relationships help identify cause and treatment:
Note: in physics stress is defines as the force applied across a unit area. Stress describes the force one part of a body applies to adjacent parts.